Is propofol anticonvulsant or proconvulsant?
نویسندگان
چکیده
منابع مشابه
Anticonvulsant and proconvulsant actions of 2-deoxy-D-glucose.
PURPOSE 2-Deoxy-D-glucose (2-DG), a glucose analog that accumulates in cells and interferes with carbohydrate metabolism by inhibiting glycolytic enzymes, has anticonvulsant actions. Recognizing that severe glucose deprivation can induce seizures, we sought to determine whether acute treatment with 2-DG can promote seizure susceptibility by assessing its effects on seizure threshold. For compar...
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The effect of acute (120 mg/kg) and chronic (25 mg/kg, twice a day, for 4 days) intraperitonial injection of the nitric oxide (NO) synthase (NOS) inhibitor NG-nitro-L-arginine (L-NOARG) was evaluated on seizure induction by drugs such as pilocarpine and pentylenetetrazole (PTZ) and by sound stimulation of audiogenic seizure-resistant (R) and audiogenic seizure-susceptible (S) rats. Seizures wer...
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In combination with propofol, alfentanil was compared with fentanyl for total i.v. anaesthesia in 29 women (ASA classes I, II) admitted for elective hysterectomy. Infusion rates of propofol and fentanyl were determined from the literature and from pilot studies, while alfentanil was given according to a computer program. Dosage was: propofol, bolus 1.5 mg kg-1, infusion 9 mg kg-1 h-1 for 10 min...
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Propofol is associated with abnormal motor events resembling seizures, the exact nature of these events remains to be elucidated. We describe here a case of seizure-like activity after propofol-induced conscious sedation accompanied by a prolactin rise, together suggesting that the event was ictal.
متن کاملWhen Propofol is Problematic
Figure 1. Representation of the electron transport chain showing the relationship of complexes I-V. Note that I and II both feed into III via the intermediate ubiquinone. Cytochrome c then receives electrons from III and passes them to complex IV. Electron flow is linked to protons pumped out of the matrix (dotted arrows). Proton gradient drives ATP formation by F0F1 ATPase (complex V). Propofo...
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ژورنال
عنوان ژورنال: Canadian Journal of Anaesthesia
سال: 1997
ISSN: 0832-610X,1496-8975
DOI: 10.1007/bf03011977